Analysis of a linkage peak NEXT

The following pages will explain how GeneSniffer works using the Type I Diabetes linkage peak at 2q33 as an example. See the full results here.

For each of the genes in a region of interest, pages of information are collected from public databases and interrogated using a list of weighted disease specific keywords. In this case the words are specific to Type I Diabetes. See the list below.

beta cell:5
beta-cell:5
beta cell function:10
beta-cell function:10
Type 1 Diabetes Mellitus:25
Type 1 Diabetes:25
Diabetes Type 1:25
DM1:10
T1D :25
IDDM:10
insulin:5
insulin Resistance:10
insulin Sensitivity:10
islet:15
pancreatic islet cell:10
Insulin-dependent diabetes:25
Insulin-dependent diabetes mellitus:25
Insulin Dependent Diabetes:25
Insulin Dependent Diabetes Mellitus:25
gluconeogenesis:5
autoimmunity:2
autoimmune:2
immune:1
cytokine:2
glucose homeostasis:10
ketoacidosis:5
polydipsia:5
polyphagia:5
polyuria:5
hyperglycemia:10
osmotic diuresis:5
secondary thirst:5
pancreatic autoimmunity:25
insulin deficiency:10
ketosis:5

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